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Brain Res. 1986 Feb 26;366(1-2):346-9.

The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting.


Mice were first administered intrastriatal injections of 6-hydroxydopamine and subsequently a sub-group was given neural cell suspension grafts prepared from 14-day-old fetal ventral mesencephalic mouse tissue. Six and 8 weeks after transplantation the mice in the grafted group exhibited a significant reduction in amphetamine-induced turning behaviour towards the lesioned side compared to non-grafted lesioned controls. Six of the 7 mice that had surviving grafts containing histofluorescent dopamine neurons eventually showed a reversed motor side bias with more amphetamine-induced turning in a direction away from the transplant.

[PubMed - indexed for MEDLINE]
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