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Cancer Invest. 2019;37(2):85-89. doi: 10.1080/07357907.2019.1565766. Epub 2019 Mar 5.

Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer.

Author information

1
a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.
2
b University of Florida Health Proton Therapy Institute , Jacksonville , Florida , USA.
3
c Department of Urology , University of Florida College of Medicine , Jacksonville , Florida , USA.

Abstract

Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60+ months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0-974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0-1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays.

KEYWORDS:

Bladder and prostate cancer; Proton therapy; Radiation oncology; Serum testosterone

PMID:
30836776
DOI:
10.1080/07357907.2019.1565766
[Indexed for MEDLINE]

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