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Bioorg Chem. 2019 Feb 22;86:705-713. doi: 10.1016/j.bioorg.2019.02.045. [Epub ahead of print]

Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties.

Author information

1
Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Chemistry 53100 Rize, Turkey. Electronic address: musa.ozil@erdogan.edu.tr.
2
Recep Tayyip Erdogan University, Education Faculty, 53200 Rize, Turkey.
3
Agri Ibrahim Cecen University, Pharmacy Faculty, 04100 Agri, Turkey.

Abstract

Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of H2O and CO2 to HCO3- and H+. CAs are found in different tissues where they participate in various significant biochemical processes such as ion transport, carbon dioxide respiration, ureagenesis, lipogenesis, bone resorption, electrolyte secretion, acid-base balance, and gluconeogenesis. In such processes, many CAs are significant therapeutic targets because of their inhibitory potentials especially in the treatment of some diseases such as edema, glaucoma, obesity, cancer, epilepsy, and osteoporosis. Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are also valuable compounds for different therapeutic applications including Alzheimer's disease. In this work, we report a fast and effective synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and also their CA and cholinesterases inhibitory properties. Our findings showed that these Schiff base derivatives, with triazole ring, found as strong CA and cholinesterases inhibitors.

KEYWORDS:

1,2,4-Triazole; Benzohydrazide; Carbonic anhydrase; Cholinesterase; Enzyme inhibition; Schiff base

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