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Nanoscale. 2019 Mar 14;11(11):4707-4711. doi: 10.1039/c8nr10354b.

Measurement of nanomechanical properties of DNA molecules by PeakForce atomic force microscopy based on DNA origami.

Author information

1
School of Science, Ningbo University, Ningbo 315211, Zhejiang, China. zhouxingfei@hotmail.com.

Abstract

Characterization of the stiffness of thin DNA strands remains difficult. By constructing bilayer DNA molecules, we investigated their mechanical properties using AFM. Increased DNA thickness through DNA origami greatly reduced the substrate effect when measuring Young's modulus, thus providing a more accurate picture of the inherent nanomechanical properties of DNA.

PMID:
30834915
DOI:
10.1039/c8nr10354b
[Indexed for MEDLINE]

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