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Value Health. 2019 Mar;22(3):267-275. doi: 10.1016/j.jval.2019.01.004.

Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report.

Author information

1
University of Sheffield, Sheffield, South Yorkshire, UK. Electronic address: j.e.brazier@sheffield.ac.uk.
2
University of Sheffield, Sheffield, South Yorkshire, UK.
3
Takeda Pharmaceutical International AG, Zurich, Switzerland.
4
Erasmus University Medical Center, Rotterdam, The Netherlands; Viersprong Institute for Studies of Personality Disorders, Halsteren, The Netherlands.
5
Celgene International Sàrl, Boudry, Switzerland.
6
APAC, Syneos Health, Tokyo, Japan.
7
Health Technology Assessment Institute, Federal University of Rio Grande du Sol, Porto Alegre, Brazil.
8
The University of Adelaide, Adelaide, Australia.
9
Acaster Lloyd Consulting Ltd, Oxford, UK.
10
Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Abstract

Cost-effectiveness models that present results in terms of cost per quality-adjusted life-year for health technologies are used to inform policy decisions in many parts of the world. Health state utilities (HSUs) are required to calculate the quality-adjusted life-years. Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, which rarely happens, analysts typically need to identify at least some additional HSUs from alternative sources. When possible, HSUs are identified by a systematic review of the literature, but, again, this rarely happens. In 2014, ISPOR established a Good Practices for Outcome Research Task Force to address the use of HSUs in cost-effectiveness models. This task force report provides recommendations for researchers who identify, review, and synthesize HSUs for use in cost-effectiveness models; analysts who use the results in models; and reviewers who critically appraise the suitability and validity of the HSUs selected for use in models. The associated Minimum Reporting Standards of Systematic Review of Utilities for Cost-Effectiveness checklist created by the task force provides criteria to judge the appropriateness of the HSUs selected for use in cost-effectiveness models and is suitable for use in different international settings.

KEYWORDS:

cost effectiveness; economic evaluation; health state utility; preference-based; quality of life; systematic reviews; utilities

PMID:
30832964
DOI:
10.1016/j.jval.2019.01.004

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