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Value Health. 2019 Mar;22(3):267-275. doi: 10.1016/j.jval.2019.01.004.

Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report.

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University of Sheffield, Sheffield, South Yorkshire, UK. Electronic address:
University of Sheffield, Sheffield, South Yorkshire, UK.
Takeda Pharmaceutical International AG, Zurich, Switzerland.
Erasmus University Medical Center, Rotterdam, The Netherlands; Viersprong Institute for Studies of Personality Disorders, Halsteren, The Netherlands.
Celgene International Sàrl, Boudry, Switzerland.
APAC, Syneos Health, Tokyo, Japan.
Health Technology Assessment Institute, Federal University of Rio Grande du Sol, Porto Alegre, Brazil.
The University of Adelaide, Adelaide, Australia.
Acaster Lloyd Consulting Ltd, Oxford, UK.
Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.


Cost-effectiveness models that present results in terms of cost per quality-adjusted life-year for health technologies are used to inform policy decisions in many parts of the world. Health state utilities (HSUs) are required to calculate the quality-adjusted life-years. Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, which rarely happens, analysts typically need to identify at least some additional HSUs from alternative sources. When possible, HSUs are identified by a systematic review of the literature, but, again, this rarely happens. In 2014, ISPOR established a Good Practices for Outcome Research Task Force to address the use of HSUs in cost-effectiveness models. This task force report provides recommendations for researchers who identify, review, and synthesize HSUs for use in cost-effectiveness models; analysts who use the results in models; and reviewers who critically appraise the suitability and validity of the HSUs selected for use in models. The associated Minimum Reporting Standards of Systematic Review of Utilities for Cost-Effectiveness checklist created by the task force provides criteria to judge the appropriateness of the HSUs selected for use in cost-effectiveness models and is suitable for use in different international settings.


cost effectiveness; economic evaluation; health state utility; preference-based; quality of life; systematic reviews; utilities


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