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Viruses. 2019 Mar 2;11(3). pii: E211. doi: 10.3390/v11030211.

Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala.

Author information

1
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. erin.harvey@sydney.edu.au.
2
Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. danielle.madden@research.usc.edu.au.
3
Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. apolking@usc.edu.au.
4
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. edward.holmes@sydney.edu.au.

Abstract

Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship between abundance and ocular disease in koalas, suggesting that the co-infection of Burpengary virus and Chlamydia pecorum is inhibited.

KEYWORDS:

Chlamydia pecorum; koala; phylogeny; picornavirus; virus discovery

PMID:
30832350
DOI:
10.3390/v11030211
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