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Liver Int. 2019 Mar 4. doi: 10.1111/liv.14086. [Epub ahead of print]

Clinical presentation, diagnosis and staging of cholangiocarcinoma.

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Liver Unit, Barcelona Clinic Liver Cancer Group, Hospital Clínic Barcelona, August Pi i Sunyer Biomedical Research Institute, CIBERehd, University of Barcelona, Barcelona, Spain.
Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Academic Diagnostic Imaging Division - I.C.O.T. Hospital, University of Rome "Sapienza", Latina, Italy.
Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)., Universidad del País Vasco (UPV/EHU), San Sebastian, Spain.
Gastrointestinal Oncology Unit, Clinica Universidad de Navarra, Programa Tumores Solidos y biomarcadrores, CIMA, Universidad de Navarra, Pamplona, Spain.
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.


Cholangiocarcinoma (CCA) is a heterogeneous group of tumours, derived from cells of the biliary tree, which represent the second most frequent primary liver tumour. According to the most recent classifications, CCA can be subdivided into intrahepatic (iCCA) and extrahepatic (eCCA) which include perihilar (pCCA) and distal (dCCA) CCA. CCA are usually identified at advanced stages, when the primary tumour grows enough to produce a large liver mass or when jaundice has developed because of biliary tree obstruction. The ongoing challenges in the identification of risk factors and definition of a specific population at higher risk of developing CCA are the main challenges for the development of screening programs. Therefore, late diagnosis remains an unresolved issue in CCA. Imaging plays an important role in the detection and characterization of CCA, helping with radiological diagnosis, guiding biopsy procedures and allowing staging of the tumour. This review focuses on clinical presentations and diagnosis and staging techniques of CCA.


cholangiocarcinoma; clinical presentation; diagnosis; jaundice; staging


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