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ChemSusChem. 2019 Jul 5;12(13):3054-3059. doi: 10.1002/cssc.201900152. Epub 2019 Apr 4.

Mn-Catalyzed Selective Double and Mono-N-Formylation and N-Methylation of Amines by using CO2.

Author information

1
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.
2
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
3
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
4
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.

Abstract

Functionalization of amines by using CO2 is of fundamental importance considering the abundance of amines and CO2 . In this context, the catalytic formylation and methylation of amines represent convenient and successful protocols for selective CO2 utilization as a C1 building block. This study represents the first example of selective catalytic double N-formylation of aryl amines by using a dinuclear Mn complex in the presence of phenylsilane. This robust system also allows for selective formylation and methylation of amines under a range of conditions.

KEYWORDS:

amines; carbon dioxide; formylation; homogeneous catalysis; manganese

PMID:
30830999
DOI:
10.1002/cssc.201900152

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