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Cardiovasc Res. 2019 Mar 4. pii: cvz058. doi: 10.1093/cvr/cvz058. [Epub ahead of print]

Inflammation: A Common Contributor to Cancer, Aging, and Cardiovascular Diseases.

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Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, Munich, Germany, Member of the German Center for Lung Research (DZL).


Inflammation participates in the pathogenesis of both cancer and to cardiovascular disease. This review examines the mechanistic commonalities between these two scourges of humanity through the lens of inflammation biology. Inflammatory pathways contribute to the initiation, the progression, and the complication of both malignant tumors and atherosclerotic plaques. Modulation of inflammatory pathways have proven transformative in the treatment of cancers and have crossed the threshold of clinical reality as treatments to reduce the risk of cardiovascular events. The recognition that clonal hematopoiesis drives both leukemia and cardiovascular events provides yet another link between these two seemingly disparate diseases. The nascent specialty of cardio-oncology has initially focused on the cardiovascular complications of cancer therapies. The recognition of a more profound pathophysiologic commonality between cancer and cardiovascular diseases should expand the concept of cardio-oncology. Embracing the mechanistic commonality and transcending traditional barriers between disciplines offers immense opportunities for speeding innovative research that can address the growing burden of both cancer and cardiovascular disease.


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