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Indian J Cancer. 2018 Oct-Dec;55(4):399-403. doi: 10.4103/ijc.IJC_325_18.

Nicotinic acetylcholine receptor gene polymorphism is not associated with tobacco-related oral squamous cell carcinoma.

Author information

1
Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.
2
Department of Otorhinolaryngology and Head and Neck Surgery, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.

Abstract

BACKGROUND:

Nicotinic acetylcholine receptor is implicated in carcinogenesis indirectly through increasing nicotine dependence and directly through its impact on cell-cycle regulation. Functional polymorphism in nicotinic acetylcholine receptor alpha-5 subunit gene (CHRNA5 c.1192G>A; rs16969968) is associated with nicotine dependence and risk of lung cancer.

AIM:

The aim of this study was to evaluate the association of CHRNA5 c.1192G>A polymorphism with the risk of oral squamous cell carcinoma (OSCC).

SETTINGS AND DESIGN:

This was a rural teaching hospital-based case-control study.

MATERIALS AND METHODS:

A total of 100 histopathologically confirmed cases of OSCC patients and 100 age- and gender-matched healthy individuals were genotyped for CHRNA5 c.1192G>A polymorphism by polymerase chain reaction-restriction fragment length polymorphism method. Allele and genotype frequencies among case and control groups were compared by Chi-squared test (Fisher's exact).

RESULTS:

The frequency of CHRNA5 c.1192A allele was 22% in OSCC patients and 26% in control individuals. The difference in the distribution of alleles and genotypes between case and control groups was not significant (P > 0.05).

CONCLUSIONS:

CHRNA5 c.1192G>A polymorphism is not associated with the risk of developing OSCC.

KEYWORDS:

CHRNA5 gene; genetic susceptibility; nicotinic acetylcholine receptor; oral squamous cell carcinoma

PMID:
30829278
DOI:
10.4103/ijc.IJC_325_18
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