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Lung India. 2019 Mar-Apr;36(2):131-138. doi: 10.4103/lungindia.lungindia_434_17.

Repeated exacerbation of asthma: An intrinsic phenotype of uncontrolled asthma.

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Department of Pulmonary Medicine, Sir Ganga Ram Hospital, New Delhi, India.
Department of Pulmonary Medicine, Fortis Hospital, Cunningham Road, Bengaluru, Karnataka, India.
Department of Pulmonary Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
Respiratory Medical Affairs, AstraZeneca Pharma India Limited, Bengaluru, Karnataka, India.


Asthma is a chronic disease of the airways affecting a large number of people across the globe. Uncontrolled asthma poses an emotional as well as the physical burden on patients and results in a great economic burden. "Exacerbation-prone phenotype" asthmatics are a cluster of patients who may suffer from more frequent and severe exacerbations than other asthmatics. Factors such as inadequate symptom control, improper adherence to medications, and incorrect use of inhalers are responsible for frequent asthma exacerbations. Caring for the patient with "exacerbation-prone asthma" needs participation from both the doctor as well as the patient. Self-management, improving knowledge about the disease, control of comorbidities, and a stepwise approach with the use of a single inhaler maintenance and reliever therapy in patients with severe asthma could help in delivering better care for the "exacerbation-prone phenotype" of asthmatics.


Exacerbation-prone; inhalers; phenotype; severe asthma

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