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Semin Nephrol. 2019 Mar;39(2):152-158. doi: 10.1016/j.semnephrol.2018.12.005.

Epigenetic Regulation in Kidney Toxicity: Insights From Cisplatin Nephrotoxicity.

Author information

1
Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, Hunan, China.
2
Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Charlie Norwood VA Medical Center, Augusta, GA.
3
Department of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, Hunan, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Charlie Norwood VA Medical Center, Augusta, GA. Electronic address: zdong@csu.edu.cn.

Abstract

Nephrotoxicity, as a result of the exposure of kidney to endogenous and exogenous toxins, is an important factor for acute kidney injury and the development of progressive chronic kidney disease. Cisplatin is among the most widely studied kidney toxicants. In the past decade, epigenetic regulation has emerged as a notable pathogenic mechanism in cisplatin nephrotoxicity, including DNA methylation, histone modification, and noncoding RNAs. In this review, we use cisplatin nephrotoxicity as an example to highlight the epigenetic alteration, function, and underlying mechanism in kidney toxicity. The study of epigenetic regulation in kidney toxicity is still in its infancy, and further investigation will bring new insights for the development of novel diagnostic biomarkers and therapeutic interventions.

KEYWORDS:

DNA methylation; Epigenetic; cisplatin nephrotoxicity; histone modification; noncoding RNAs

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