Send to

Choose Destination
Curr Neurovasc Res. 2019 Feb 27. doi: 10.2174/1567202616666190227202638. [Epub ahead of print]

Risk Factors for Aphasia in Cerebral Small Vessel Diseases

Author information

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Department of Geriatric Medicine, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Fujian Medical University, Fuzhou, Fujian, China.



Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors for aphasia in cSVD patients.


This study retrospectively analyzed 38 patients, with and without aphasia, aged 50 or over, Chinese Han population, diagnosed as cSVD with lacunes and/or WMH. We collected demographic characteristics and vascular risk factors. The severity of WMH was assessed by the Age Related White Matter Changes (ARWMC) rating scale.


Risk factors associated with aphasia were lower education (p = 0.029), higher total cholesterol (TC) level (p = 0.023) and higher low-density lipoprotein cholesterol (LDL-C) level (p = 0.027). After controlling for age and sex, level of TC (odds ratios, 1.96; 95% confidence interval, 1.06-3.62; p = 0.032) remained associated with aphasia independently.


High level of TC was significantly associated with a higher risk of aphasia in clinically silent cSVD patients. Early interventions including lipid-lowering treatment, cranial MRI and ARWMC rating scale should be performed. Further studies are needed to explore proper methods of prevention and treatment for aphasia in clinically silent cSVD patients, in addition to understanding the pathophysiological mechanism.


WMH; aphasia; cSVD; cerebral small vessel disease; lacune; risk factors; white matter hyperintensities

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center