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Anaerobe. 2019 Feb 28;57:1-3. doi: 10.1016/j.anaerobe.2019.02.016. [Epub ahead of print]

Dietary therapy for clostridium difficile colonization: A case series.

Author information

1
Department of Pediatrics, Division of Gastroenterology, Seattle Children's Hospital and University of Washington, Seattle, WA, USA. Electronic address: david.suskind@seattlechildrens.org.
2
Department of Pediatrics, Division of Gastroenterology, Seattle Children's Hospital and University of Washington, Seattle, WA, USA.
3
Department of Nutrition, Seattle Children's Hospital, Seattle, WA, USA.
4
Department of Microbiology, University of Washington, Seattle, WA, 98195, USA.
5
Department of Microbiology, University of Washington, Seattle, WA, 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, 98195, USA; Department of Medicine, University of Washington, Seattle, WA, 98195, USA; Department of Immunology, University of Washington, Seattle, WA, 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.

Abstract

Clostridium difficile (C. difficile) is an important nosocomial pathogen in adults and children. Roughly 4-5% of non hospitalized healthy adults carry the organism in their intestinal flora while adults in long term care facilities have asymptomatic carriage rates estimated at 20-50%. C. difficile colonization results in a spectrum of clinical conditions from asymptomatic carrier state to fulminant colitis. Changes in the fecal microbiome are central in the development of C. difficile colonization and disease pathogenesis. C. difficile infection has been shown to be associated with reduced biodiversity of the gut microbiome and intestinal dysbiosis. With the importance of the intestinal microbiota in development of CDI and with the known impact of diet on the intestinal microbiota, we report the first known case of C. difficile colonization/recurrence successful treated by dietary modification.

KEYWORDS:

Clostridium difficile; Colonization; Diet; Microbiome; Nutrition; Pediatrics; Specific carbohydrate diet

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