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J Allergy Clin Immunol. 2019 Feb 27. pii: S0091-6749(19)30279-9. doi: 10.1016/j.jaci.2019.02.016. [Epub ahead of print]

The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy.

Author information

1
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2
Benaroya Research Institute, Seattle, WA, USA; Immune Tolerance Network, San Francisco, CA, USA.
3
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
4
Department of Medicine, University of Colorado, Anschutz, CO, USA.
5
Immune Tolerance Network, San Francisco, CA, USA.
6
Benaroya Research Institute, Seattle, WA, USA.
7
Immune Tolerance Network, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
8
Allergy, Asthma and Airway Biology Branch, DAIT, NIAID, Bethesda, MD, USA.
9
Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London, and Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
10
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: rmathias@jhmi.edu.

Abstract

We identified a strong association between peanut allergy and the MALT1 locus in LEAP participants in the peanut avoidance group with 58.6% of carriers developing peanut allergy at 60 months as compared to 12.7% of non-carriers.

KEYWORDS:

GWAS; IgE; MALT1; Peanut allergy; early allergen exposure; food allergy; immunogenetics

PMID:
30825465
DOI:
10.1016/j.jaci.2019.02.016
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