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Dig Dis Sci. 2019 Mar 2. doi: 10.1007/s10620-019-05556-z. [Epub ahead of print]

Association Between Cannabis Use and Complications Related to Crohn's Disease: A Retrospective Cohort Study.

Author information

1
John H Stroger Hospital of Cook County, Chicago, IL, USA. chimeziembachi@gmail.com.
2
, Chicago, USA. chimeziembachi@gmail.com.
3
John H Stroger Hospital of Cook County, Chicago, IL, USA.
4
Rush University Medical Centre, Chicago, IL, USA.
5
Gastroenterology and Hepatology Department, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
6
SUNY Downstate Medical Centre, New York, NY, USA.

Abstract

BACKGROUND:

Crohn's disease is an idiopathic inflammatory process that is occasionally associated with complications, which cause significant morbidity and mortality. The anti-inflammatory effect of cannabis in intestinal inflammation has been shown in several experimental models; it is unknown whether this correlates with fewer complications in Crohn's disease patients.

AIMS:

To compare the prevalence of Crohn's disease-related complications among cannabis users and non-users in patients admitted with a primary diagnosis of Crohn's disease or a primary diagnosis of Crohn's related complication and a secondary diagnosis of Crohn's disease between 2012 and 2014.

METHODS:

We used data from the Healthcare Cost and Utilization Project-National Inpatient Sample. Cannabis users (615) were compared directly after propensity score match to non-users, in aspects of various complications and clinical end-points.

RESULTS:

Among matched cohorts, Cannabis users were less likely to have the following: active fistulizing disease and intra-abdominal abscess (11.5% vs. 15.9%; aOR 0.68 [0.49 to 0.94], p = 0.025), blood product transfusion (5.0% vs. 8.0%; aOR 0.48 [0.30 to 0.79], p = 0.037), colectomy (3.7% vs. 7.5%; aOR 0.48 [0.29-0.80], p = 0.004), and parenteral nutrition requirement (3.4% vs. 6.7%, aOR 0.39 [0.23 to 0.68], p = 0.009).

CONCLUSION:

Cannabis use may mitigate several of the well-described complications of Crohn's disease among hospital inpatients. These effects could possibly be through the effect of cannabis in the endocannabinoid system.

KEYWORDS:

Cannabis; Complications; Crohn’s; Parenteral nutrition

PMID:
30825109
DOI:
10.1007/s10620-019-05556-z

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