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J Rheumatol. 2019 Mar 1. pii: jrheum.171405. doi: 10.3899/jrheum.171405. [Epub ahead of print]

Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System (PROMIS) in Systemic Vasculitis.

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From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Reykjavik; Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Iceland; Division of Rheumatology, Division of General Internal Medicine, Department of Family Medicine and Community Health & Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, USA; University of Pennsylvania, Philadelphia, PA; Nuffield Department of Population Health (HSRU), University of Oxford, Old Road Campus, Oxford; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Rheumatology, University of Ottawa, Ottawa, Canada; Division of Rheumatology, St. Joseph's Healthcare, McMaster University, Hamilton, ON,;Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Division of Rheumatology, Mount Sinai Hospital, Toronto, ON; Division of Rheumatology, University of Utah, Salt Lake City, UT; Department of Rheumatology, Cleveland Clinic, Cleveland, OH; Section of Rheumatology, Boston University School of Medicine, Boston; Division of Pulmonology and Critical Care Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. This work was supported by The Vasculitis Clinical Research Consortium (VCRC) (U54 AR057319 and R01 AR 064153) which is part of the Rare Diseases Clinical Research Network (RDCRN), an initiative of the Office of Rare Diseases Research (ORDR), National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603 ). Address correspondence to Gunnar Tomasson, Assistant professor of epidemiology, Faculty of Medicine, University of Iceland. Sturlugata 8, 101 Reykjavik, Iceland. E-mail:



The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis.


Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Short Form 36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician- and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures.


During the study period 973 subjects came for 2,306 study visits and the PROMIS collection was completed at 2,276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40-55 seconds. PROMIS instruments correlated crosssectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS Fatigue correlated with both the Physical Component Score (PCS) (r=-0.65) and with the Mental Component Score (MCS) (r=-0.54). PROMIS Physical Function correlated strongly with PCS (r=0.81) but weakly with MCS (r=0.29). Weaker correlations were obseĀ¬rved longitudinally between change in PROMIS scores with change in PCS and MCS.


Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.


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