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Int J Mol Sci. 2019 Feb 28;20(5). pii: E1051. doi: 10.3390/ijms20051051.

Lipidomics of Bioactive Lipids in Acute Coronary Syndromes.

Author information

1
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, MB R2H 2A6, Canada. solatiz@myumanitoba.ca.
2
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada. solatiz@myumanitoba.ca.
3
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, MB R2H 2A6, Canada. aravandi@sbgh.mb.ca.
4
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada. aravandi@sbgh.mb.ca.
5
Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, 409 Tache Avenue, Winnipeg, MB R2H 2A6, Canada. aravandi@sbgh.mb.ca.

Abstract

Acute coronary syndrome (ACS) refers to ischemic conditions that occur as a result of atherosclerotic plaque rupture and thrombus formation. It has been shown that lipid peroxidation may cause plaque instability by inducing inflammation, apoptosis, and neovascularization. There is some evidence showing that these oxidized lipids may have a prognostic value in ACS. For instance, higher levels of oxidized phospholipids on apo B-100 lipoproteins (OxPL/apoB) predicted cardiovascular events independent of traditional risk factors, C-reactive protein (hsCRP), and the Framingham Risk Score (FRS). A recent cross-sectional study showed that levels of oxylipins, namely 8,9-DiHETrE and 16-HETE, were significantly associated with cardiovascular and cerebrovascular events, respectively. They found that with every 1 nmol/L increase in the concentrations of 8,9-DiHETrE, the odds of ACS increased by 454-fold. As lipid peroxidation makes heterogonous pools of secondary products, therefore, rapid multi-analyte quantification methods are needed for their assessment. Conventional lipid assessment methods such as chemical reagents or immunoassays lack specificity and sensitivity. Lipidomics may provide another layer of a detailed molecular level to lipid assessment, which may eventually lead to exploring novel biomarkers and/or new treatment options. Here, we will briefly review the lipidomics of bioactive lipids in ACS.

KEYWORDS:

bioactive lipids; coronary disease; ischemia reperfusion injury; ischemic heart disease; lipids; mass spectrometry; myocardial infarction; oxidized phospholipids; oxylipins

PMID:
30823404
PMCID:
PMC6429306
DOI:
10.3390/ijms20051051
[Indexed for MEDLINE]
Free PMC Article

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