Risk Factors for Restenosis After Carotid Revascularization: A Meta-Analysis of Hazard Ratios

Background: Carotid artery restenosis after carotid endarterectomy (CEA) or carotid artery stenting (CAS) will occur in 3%-30% of cases. Restenosis can lead to more frequent clinical and imaging monitoring and the potential for reoperation. We sought to define the demographic, clinical, and radiographic characteristics that influence the restenosis risk after carotid revascularization.

Methods: The present study was performed in accordance with the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. A random effects model meta-analysis of hazard ratios (HRs) was conducted.

Results: Eighteen studies with 17,106 patients were included. Diabetes (HR, 1.68; 95% confidence interval [CI], 1.00-2.83; I², 76.7%), dyslipidemia (HR, 1.77; 95% CI, 1.08-2.91; I², 22.5%), female gender (HR, 1.50; 95% CI, 1.14-1.98, I², 0%), chronic kidney disease (HR, 4.15; 95% CI, 1.69-10.19; I², 44.5%), hypertension (HR, 1.99; 95% CI, 1.07-3.72; I², 68%), smoking (HR, 1.65; 95% CI, 1.15-2.37; I², 54.3%), and pretreatment stenosis >70% (HR, 1.04; 95% CI, 1.0-1.08; I², 0%) showed a statistically significant increase in restenosis risk after carotid revascularization. Subgroup analyses of CEA and CAS showed that female gender and smoking status were significantly associated with recurrent stenosis after CEA but not after CAS. In contrast, hypertension was associated with restenosis after CAS but not after CEA. Patch endarterectomy (HR, 0.33; 95% CI, 0.22-0.50; I², 0%) and symptomatic status at presentation in the CAS group (HR, 0.61; 95% CI, 0.41-0.90; I², 0%) were associated with a decreased risk of restenosis. Antiplatelet use and coronary artery disease were not associated with restenosis risk.

Conclusions: Diabetes, dyslipidemia, female gender, renal failure, hypertension, and smoking were associated with an increased risk of restenosis, and patch endarterectomy and symptomatic status at presentation were associated with a decreased risk of carotid restenosis. Both female gender and current smoking status were only associated with recurrent stenosis after CEA, and hypertension was only associated with restenosis after CAS.