Format

Send to

Choose Destination
Brain Imaging Behav. 2019 Mar 1. doi: 10.1007/s11682-019-00071-1. [Epub ahead of print]

Schizophrenia-related abnormalities in the triple network: a meta-analysis of working memory studies.

Wu D1,2,3, Jiang T4,5,6,7,8,9.

Author information

1
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Hai Dian District, Zhong Guan Cun East Road 95, Beijing, 100190, China.
2
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
3
University of Chinese Academy of Sciences, Beijing, China.
4
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Hai Dian District, Zhong Guan Cun East Road 95, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
5
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
6
University of Chinese Academy of Sciences, Beijing, China. jiangtz@nlpr.ia.ac.cn.
7
CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
8
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 625014, China. jiangtz@nlpr.ia.ac.cn.
9
The Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia. jiangtz@nlpr.ia.ac.cn.

Abstract

Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the default mode network have also been reported in schizophrenia but have received less attention. Our goal was to discover whether deactivation abnormalities can also be consistently found in schizophrenia during working memory tasks and, further, to consider both activation and deactivation abnormalities. Fifty-two English language peer-reviewed studies were included in this meta-analysis. Compared with normal controls, the schizophrenia patients showed activation dysfunction of the bilateral dorsolateral prefrontal cortex and posterior parietal cortex as well as the anterior insula, anterior cingulate cortex, and supplementary motor area, which are core nodes of the central executive and salience network. In addition to dysfunction of the activation networks, the patients showed deactivation abnormalities in the ventral medial prefrontal cortex and posterior cingulate cortex, which are core nodes of the default mode network. These results suggest that both activation and deactivation abnormalities exist in schizophrenia patients and that these abnormalities should both be considered when investigating the pathophysiological mechanism of schizophrenia.

KEYWORDS:

Meta-analysis; Neuroimaging; Schizophrenia; Working memory

PMID:
30820860
DOI:
10.1007/s11682-019-00071-1

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center