Format

Send to

Choose Destination
Cancer Causes Control. 2019 Apr;30(4):385-393. doi: 10.1007/s10552-019-01149-3. Epub 2019 Feb 28.

Statin use after diagnosis is associated with an increased survival in esophageal cancer patients: a Belgian population-based study.

Author information

1
Pôle d'Épidémiologie et Biostatistique, Université Catholique de Louvain (UCL), Institut de Recherche Expérimentale et Clinique (IREC), Clos Chapelle-aux-champs, 30 bte B1.30.13, 1200, Brussels, Belgium. olivia.lacroix@uclouvain.be.
2
Pôle d'Épidémiologie et Biostatistique, Université Catholique de Louvain (UCL), Institut de Recherche Expérimentale et Clinique (IREC), Clos Chapelle-aux-champs, 30 bte B1.30.13, 1200, Brussels, Belgium.
3
Research Department, Belgian Cancer Registry, Rue Royale 215, 1210, Brussels, Belgium.
4
Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, Northern Ireland, UK.

Abstract

PURPOSE:

Preclinical studies have shown that statins reduce proliferation in esophageal cancer. Three recent observational studies have shown encouraging results but suffered from limitations. This work aimed to assess at the Belgian population level whether statin usage was associated with a decreased mortality in esophageal cancer patients.

METHODS:

We conducted an observational, population-based study by linking data of the Belgian Cancer Registry (BCR) with medical claims data coming from health insurance companies and mortality records collected by regional governments for patients diagnosed with esophageal cancer between 2004 and 2014. Using time-dependent Cox regression models, hazard ratios (HRs) and 95% confidence intervals (CI) for overall and cancer-specific mortality were calculated.

RESULTS:

Of 6,238 patients with stage I-III esophageal cancer, post-diagnostic use of statins was found in 1,628 (26%) patients. Statins use after diagnosis was associated with a reduction in overall mortality (adjusted HR = 0.84, 95% CI [0.77; 0.92]) and cancer-specific mortality (adjusted HR = 0.87, 95% CI [0.78; 0.97]). Similar association were also seen for pre-diagnostic statin use in overall (adjusted HR = 0.83, 95% CI [0.76-0.91]) and cancer-specific analysis (adjusted HR = 0.86, 95% CI [0.77-0.96]).

CONCLUSIONS:

In this large cohort of Belgian patients with esophageal cancer, statins use after diagnosis was associated with a decreased mortality.

KEYWORDS:

Epidemiology; Esophageal cancer; Pharmacoepidemiology; Statin; Survival

PMID:
30820714
DOI:
10.1007/s10552-019-01149-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center