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Bio Protoc. 2019 Jan 20;9(2). pii: e3140. doi: 10.21769/BioProtoc.3140.

A Mouse Model of Postoperative Pain.

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Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.


Postoperative pain is highly debilitating and hinders recovery. Opioids are the main pain medication used for acute postoperative pain. Given the devastating opioid addiction and overdose epidemic across the US, non-opioid pain therapeutics are desperately needed. In order to develop novel, non-opioid therapies for the treatment of postoperative pain and identify the mechanisms underlying this pain, rodent models of incisional pain have been established. The protocol herein describes in detail how to create a mouse model of postoperative pain that was adapted from established protocols. This model of postoperative pain is frequently-used, highly reproducible, and results in peripheral and central nervous system alterations.


Hypersensitivity; Inflammatory pain; Mouse; Plantar incision; Postoperative pain; Skin and muscle incision

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