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Int J Prev Med. 2019 Feb 12;10:24. doi: 10.4103/ijpvm.IJPVM_83_16. eCollection 2019.

Does Chorionic Villus Sampling Increase the Risk of Preeclampsia or Gestational Hypertension?

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Department of Obstetrics and Gynecology, Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.



Chorionic villus sampling (CVS) and amniocentesis are two methods for prenatal diagnosis. The goal of this study was to compare amniocentesis and CVS-related complications in a large sample of Iranian women.


Medical records of 1624 women who underwent amniocentesis or CVS due to medical indications between 2008 and 2016 were reviewed. Data regarding age, gravidity, parity, gestational age, type of procedure, neonatal weight (and percentile), trisomia, abortion, intrauterine growth restriction (IUGR), severe IUGR, preeclampsia, and gestational hypertension were recorded.


Finally, 1215 cases were evaluated. Mean maternal age, gravidity, and gestational age were significantly different between two groups. Preeclampsia, gestational hypertension, IUGR, severe IUGR, and intrauterine fetal death were not significantly different between two groups. Trisomy 18 and 21 were common in cases underwent amniocentesis.


Women who underwent CVS are not at higher risk for developing hypertensive disorders than women underwent amniocentesis.


Amniocentesis; chorionic villus sampling; intrauterine growth restriction; preeclampsia

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