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Science. 2019 Mar 1;363(6430):975-978. doi: 10.1126/science.aau8956.

Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory.

Author information

1
Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892, USA.
2
Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA.
3
Department of Neurobiology, Duke University, Durham, NC 27710, USA.
4
Office of the Clinical Director, NINDS, National Institutes of Health, Bethesda, MD 20892, USA.
5
Department of Physics, Duke University, Durham, NC 27710, USA.
6
Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892, USA. kareem.zaghloul@nih.gov.

Abstract

Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.

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PMID:
30819961
PMCID:
PMC6478623
DOI:
10.1126/science.aau8956
[Indexed for MEDLINE]
Free PMC Article

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