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Pediatr Clin North Am. 2019 Apr;66(2):403-423. doi: 10.1016/j.pcl.2018.12.009.

Intrauterine Growth Restriction: Postnatal Monitoring and Outcomes.

Author information

1
Division of Neonatology & Developmental Biology, Department of Pediatrics, David Geffen School of Medicine at UCLA, UCLA Mattel Children's Hospital, 10833 Le Conte Avenue, B2-413 MDCC, Los Angeles, CA 90095, USA. Electronic address: kkesavan@mednet.ucla.edu.
2
Department of Pediatrics, David Geffen School of Medicine at UCLA, UCLA Mattel Children's Hospital, 10833 Le Conte Avenue, 22-412 MDCC, Los Angeles, CA 90095, USA.

Abstract

Intrauterine growth restriction (IUGR) is an important cause of fetal, perinatal and neonatal morbidity and mortality. IUGR occurs because of multiple reasons. Neonates with IUGR experience acute problems in the perinatal and early neonatal period that can be life-threatening. The unfavorable uterine environment causing growth restriction results in programming that predisposes IUGR infants to long-term health issues such as poor physical growth, metabolic syndrome, cardiovascular disease, neurodevelopmental impairment and endocrine abnormalities, warranting careful monitoring. It is imperative to strike the balance between achieving optimal catch-up to promote normal development, while preventing the onset of cardiovascular and metabolic disorders in the long-term.

KEYWORDS:

Fetal programming; Growth hormone; Intrauterine growth restriction (IUGR); Metabolic programming; Small for gestational age (SGA)

PMID:
30819345
DOI:
10.1016/j.pcl.2018.12.009
[Indexed for MEDLINE]

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