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Life Sci. 2019 Apr 1;222:46-52. doi: 10.1016/j.lfs.2019.02.050. Epub 2019 Feb 26.

The neuroprotective effect of vitamin E on waterpipe tobacco smoking-induced memory impairment: The antioxidative role.

Author information

1
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: khalzoubi@just.edu.jo.
2
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan; Departments of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana'a, Yemen.
3
Division of Physical Education, Department Educational Sciences, Qatar University, Doha 2713, Qatar; Division of Physical Therapy, Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
4
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Jordan.

Abstract

AIMS:

Tobacco smoking is associated with a vast range of adverse health effects, including diminished cognitive and anti-oxidative capabilities. Conversely, vitamin E (VitE) is known to enhance data acquisition and retention and hippocampal oxidative defense. No studies, however, examined the protective effect of VitE with tobacco administration. Therefore, this study examined the protective effect of VitE on the cognitive and oxidative debilitating effects induced by waterpipe smoking.

MATERIALS AND METHODS:

Wistar male rats were divided into four groups: waterpipe smoking, VitE, waterpipe combined with VitE, and control group. The exposure to waterpipe and VitE was for one month and then spatial learning and memory were assesses using Radial Arms Water Maze. Additionally, oxidative stress biomarkers (Catalase, GPx, and TBARS, GSH, GSSG, and GSH/GSSG ratio) were assessed in the hippocampus.

KEY FINDINGS:

The results revealed that waterpipe smoking impaired short-term and long-term memory (P < 0.05). Waterpipe smoking reduced activity of catalase (P < 0.05), GPx (P < 0.05) and GSH/GSSG ratio (P < 0.05) in the hippocampus. Administration of VitE prevented memory impairment and alterations in oxidative stress biomarkers.

SIGNIFICANCE:

waterpipe smoking induces short-term and long-term memory impairments, which were prevented by administration of VitE via its anti-oxidative properties.

KEYWORDS:

Learning; Memory; Oxidative stress; Tobacco smoking; Vitamin E; Waterpipe

PMID:
30817915
DOI:
10.1016/j.lfs.2019.02.050

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