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Acta Obstet Gynecol Scand. 2019 May;98(5):672-677. doi: 10.1111/aogs.13598. Epub 2019 Mar 25.

Cellular therapies for the endometrium: An update.

Author information

1
Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, and Karolinska University Hospital, Solna, Sweden.
2
Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
3
Department of Obstetrics and Gynecology, University of Valencia/INCLIVA, Valencia, Spain.

Abstract

An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis-promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long-term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.

KEYWORDS:

Asherman's syndrome; cell therapy; endometrial disease; female infertility

PMID:
30815850
DOI:
10.1111/aogs.13598

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