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Food Sci Biotechnol. 2018 Jul 12;28(1):261-267. doi: 10.1007/s10068-018-0433-y. eCollection 2019 Feb.

Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease.

Author information

1
1Department of Integrated Biological Science, Pusan National University, Busan, 46241 Korea.
2
2Department of Asian Food and Culinary Arts, Youngsan University, Busan, 48015 Korea.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders. Possible links have been recently found between the gut-microbiota and the host metabolism in development of NAFLD and obesity. Therefore, understanding the changes in intestinal microbiota during the progression of NAFLD, is important. In this study, the effect of Kombucha tea (KT), obtained by microbial fermentation of sugared black tea, was investigated on gut-microbiota during the progression of NAFLD. The results indicated a decrease in Erysipelotrichia class by treatment with KT in comparison to the methionine/choline-deficient (MCD)-fed db/db mice. Allobaculum, Turicibacter, and Clostridium genera, were only detected in MCD-fed db/db mice and were decreased after treatment with KT, whereas Lactobacillus was more abundant in MCD + KT-fed mice than in MCD only-fed mice and Mucispirillum, was found only in the MCD + KT-fed mice group. Our results demonstrated that the change of intestinal microbiota was influenced by KT intake, contributing to combat NAFLD.

KEYWORDS:

Gut-microbiota; Kombucha tea; Liver protection; Non-alcoholic fatty liver disease

Conflict of interest statement

Compliance with ethical standardsThe authors declare no conflict of interest.

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