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SAGE Open Med Case Rep. 2019 Feb 21;7:2050313X19832160. doi: 10.1177/2050313X19832160. eCollection 2019.

Striking lung cancer response to self-administration of cannabidiol: A case report and literature review.

Author information

1
Cancer Centre, Royal Stoke University Hospital, University Hospitals of North Midlands (UHNM), Stoke on Trent, UK.
2
Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Stoke on Trent, UK.
3
Imaging Department, Royal Stoke University Hospital, University Hospitals of North Midlands (UHNM), Stoke on Trent, UK.
4
Histopathology Department, Royal Stoke University Hospital, University Hospitals of North Midlands (UHNM), Stoke on Trent, UK.

Abstract

In spite of new drugs, lung cancer is associated with a very poor prognosis. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow-up. Thus, new drugs or re-evaluation of existing therapies used to treat other non-malignant diseases (drug repurposing) are still needed. While this research both in vitro and in vivo is being carried out, it is important to be attentive to patients where the disease responds to treatments not considered standard in clinical practice. We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer.

KEYWORDS:

Lung cancer; cannabidiol; cannabinoid

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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