Format

Send to

Choose Destination
Clin Rheumatol. 2019 Feb 27. doi: 10.1007/s10067-019-04464-x. [Epub ahead of print]

Diagnostic accuracy of anti-keratin antibody for rheumatoid arthritis: a meta-analysis.

Wang XP1,2, Cheng QY1,2, Gu MM1,2, Leng RX1,2, Fan YG1,2, Li BZ3,4, Ye DQ5,6.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
2
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, 230032, Anhui, China.
3
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. libaozhu@ahmu.edu.cn.
4
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, 230032, Anhui, China. libaozhu@ahmu.edu.cn.
5
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China. ydqahmu@126.com.
6
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, 230032, Anhui, China. ydqahmu@126.com.

Abstract

OBJECTIVES:

Anti-keratin antibody (AKA) is a serum antibody for patients with rheumatoid arthritis (RA), and it has a high specificity. Diagnostic role of AKA in RA was evaluated in this study.

METHODS:

PubMed, EMBASE, and Web of Science were searched to acquire eligible studies. Articles published before 15 March 2018 were considered to be included. Quality Assessment of Diagnostic Accuracy Studies 2 was used to evaluate the risk of bias and application concern of the included articles. Pooled analysis of diagnostic indicators of AKA for RA was conducted by using a random effects model. Subgroup analysis was employed to explore the potential influencing factors. RevMan 5.3, Stata 11.0, and Meta-DiSc 1.4 software were used in this study.

RESULTS:

A total of 15 studies (2350 positive and 2067 negative participants) were included. The pooled sensitivity was 0.46 (95% CI 0.44-0.48), pooled specificity was 0.94 (95% CI 0.93-0.95), and pooled diagnostic odds ratio was 15.86 (95% CI 9.48-26.52). In addition, the area under the curve was 0.7194.

CONCLUSIONS:

The current evidence indicated that AKA has high diagnostic specificity in RA and may be useful for RA diagnostic application in clinic.

KEYWORDS:

Anti-keratin antibody (AKA); Diagnostic; Meta-analysis; Rheumatoid arthritis (RA)

PMID:
30810911
DOI:
10.1007/s10067-019-04464-x

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center