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Int Rev Psychiatry. 2019 Feb 27:1-8. doi: 10.1080/09540261.2018.1551191. [Epub ahead of print]

The international postpartum depression: action towards causes and treatment (PACT) consortium.

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a Department of Psychiatry , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
b Department of Genetics , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
c Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.


The International Postpartum depression: Action towards Causes and Treatment (PACT) Consortium was founded with the overarching goal of creating an international perinatal psychiatry consortium to conduct novel investigations with large sample sizes to understand the genetic signature of perinatal mood disorders. PACT uses a collaborative and team science approach that includes investigators across 19 institutions and seven continents. The large sample sizes allow for statistically rigorous analyses to investigate perinatal psychiatric disorders, with an initial focus on postpartum depression (PPD). Our current aims are to identify clinical sub-types of PPD that contribute diagnostic heterogeneity, and to elucidate the genetic basis of PPD by conducting the first large genome-wide association study of PPD. To accomplish the latter aim, we are partnering with the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. To date, our consortium members have recruited 17,912 participants and 11,344 participants have been identified using the PPD ACT mobile app, of which 8,432 are PPD cases. Ultimately, we hope this approach will improve detection, diagnosis, and treatment of women who suffer from perinatal psychiatric disorders.


PACT Consortium; Perinatal psychiatry; genetics; postpartum depression; symptom heterogeneity

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