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Sci Rep. 2019 Feb 26;9(1):2813. doi: 10.1038/s41598-019-39049-w.

New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population.

Author information

1
Department of Diabetes, Endocrinology and Metabolism of Medicine, Fukushima Medical University, 960-1295, Fukushima City, Fukushima, Japan.
2
Department of Internal Medicine, Shirakawa Kosei General Hospital, Shirakawa City, 961-0005, Fukushima, Japan.
3
Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, 960-1295, Fukushima, Japan.
4
Department of Cardiology, Nakagami Hospital, 610 Noborikawa, 904-2142, Okinawa, Japan.
5
Department of Metabolism and Endocrinology, Juntendo University School of Medicine, Bunkyo, 113-8421, Tokyo, Japan.
6
Department of Internal Medicine, Fukushima Rosai Hospital, Iwaki City, 973-8403, Fukushima, Japan.
7
Department of Diabetes, Endocrinology and Metabolism of Medicine, Fukushima Medical University, 960-1295, Fukushima City, Fukushima, Japan. mshimabukuro-ur@umin.ac.jp.

Abstract

The Framingham Risk Score (FRS) has been reported to predict coronary heart disease (CHD), but its assessment has been unsuccessful in Asian population. We aimed to assess FRS and Suita score (a Japanese CHD prediction model) in a Japanese nation-wide annual health check program, participants aged 40-79 years were followed up longitudinally from 2008 to 2011. Of 35,379 participants analyzed, 1,234 had new-onset CHD. New-onset CHD was observed in diabetic men [6.00%], non-diabetic men [3.96%], diabetic women [5.51%], and non-diabetic women [2.86%], respectively. Area under the curve (AUC) of receiver operating characteristic (ROC) curve for CHD prediction were consistently low in Suita score (TC), FRS (TC) and NCEP-ATPIII FRS (TC), suggesting that these scores have only a limited power. ROC, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA) and Hosmer-Lemeshow goodness-of-fit test did not show clear differences between Suita score (TC) and FRS (TC). New models combining waist circumference ≥85 cm in men or proteinuria ≥1+ in women to Suita score (TC) was superior in diabetic men and women. New models could be useful to predict 3-year risk of CHD at least in Japanese population especially in diabetic population.

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