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Blood. 2019 May 2;133(18):1943-1952. doi: 10.1182/blood-2018-10-808873. Epub 2019 Feb 26.

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities.

Author information

1
Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH; and.
2
Department of Cell, Developmental and Regenerative Biology.
3
Developmental and Stem Cell Biology Multidisciplinary Training, Graduate School of Biomedical Sciences.
4
Black Family Stem Cell Institute, and.
5
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

Abstract

The hematopoietic system produces new blood cells throughout life. Mature blood cells all derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew to maintain the stem cell pool and to insure the continuous replenishment of blood cells. Mitochondria have recently emerged as critical not only for HSC differentiation and commitment but also for HSC homeostasis. Mitochondria are dynamic organelles that orchestrate a number of fundamental metabolic and signaling processes, producing most of the cellular energy via oxidative phosphorylation. HSCs have a relatively high amount of mitochondria that are mostly inactive. Here, we review recent advances in our understanding of the role of mitochondria in HSC homeostasis and discuss, among other topics, how mitochondrial dynamism and quality control might be implicated in HSC fate, self-renewal, and regenerative potential.

PMID:
30808633
PMCID:
PMC6497515
[Available on 2020-05-02]
DOI:
10.1182/blood-2018-10-808873

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