Format

Send to

Choose Destination
BMC Pulm Med. 2019 Feb 26;19(1):53. doi: 10.1186/s12890-019-0810-1.

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis.

Author information

1
Department of Respiratory and Critical Care, West China School of Medicine and West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China.
2
Department of Respiratory Medicine, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu, 610031, Sichuan, China.
3
Department of Respiratory and Critical Care, West China School of Medicine and West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China. liangbinmiao@163.com.

Abstract

BACKGROUND:

Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).

METHODS:

Electronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. The primary outcome was mortality. Random-effect model was used for quantitative synthesis of the adjusted odds ratio (aOR).

RESULTS:

We identified 24 trials in our final analysis. Statistical heterogeneity was found between hyperoxia and normoxia groups in patients with mechanical ventilation (I2 = 92%, P < 0.01), cardiac arrest(I2 = 63%, P = 0.01), traumatic brain injury (I2 = 85%, P < 0.01) and post cardiac surgery (I2 = 80%, P = 0.03). Compared with normoxia, hyperoxia was associated with higher mortality in overall patients (OR 1.22, 95% CI 1.12~1.33), as well as in the subgroups of cardiac arrest (OR 1.30, 95% CI 1.08~1.57) and extracorporeal life support (ELS) (OR 1.44, 95% CI 1.03~2.02).

CONCLUSIONS:

Hyperoxia would lead to higher mortality in critically ill patients especially in the patients with cardiac arrest and ELS.

KEYWORDS:

Hyperoxia; Meta-analysis; Mortality

PMID:
30808337
PMCID:
PMC6390560
DOI:
10.1186/s12890-019-0810-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center