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Sci Data. 2019 Feb 26;6:190031. doi: 10.1038/sdata.2019.31.

Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells.

Author information

1
State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
2
Division of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.
3
Plastic Surgery Department, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) show considerable promise for clinical applications in regenerative medicine. We performed a large-scale single-cell transcriptomic sequencing of 24,358 cultured human ADSCs from three donors. We provide a high-quality dataset, which would be a valuable resource for dissecting the intrapopulation heterogeneity of cultured ADSCs as well as interrogating lineage priming patterns for any interested lineages at single-cell resolution.

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