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Cranio. 2019 Feb 26:1-7. doi: 10.1080/08869634.2019.1581470. [Epub ahead of print]

Treatments of sleep bruxism in children: A systematic review and meta-analysis.

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a Department of Oral and Maxillofacial Sciences , Sapienza University of Rome , Rome , Italy.



Treatment of sleep bruxism (SB) in children is not well established. The aim of this study was to develop evidence-based recommendations on SB therapy in children between the ages of 2 and 17.


A systematic review and meta-analysis was conducted. Literature searches were performed using MedLine (PubMed), Web of Science, Scopus, and the Cochrane Library (November 30 2017).


The search strategy identified 268 potential articles; 10 papers were included in the qualitative synthesis and 3 in the meta-analysis, for a total of 94 patients. Hydroxyzine therapy showed the strongest efficacy on SB (OR 10.63; CI 95%, 1.48 to 76.08). Flurazepam and Melissa officinalis therapies presented lower grades of association with decreased SB symptoms.


Data on treatments of SB in children are limited. Future studies with a proper design, conducted on a meaningful number of patients, and based on standardized and developed diagnostic criteria are desperately needed.


Sleep bruxism; children; electromyography (EMG); meta-analysis; systematic review; treatment

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