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J Environ Pathol Toxicol Oncol. 2019;38(1):41-50. doi: 10.1615/JEnvironPatholToxicolOncol.2018027172.

Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats.

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Medical Clinic of Shangluo Central Hospital, Shangluo, Shaanxi Province, China-726000.
Department of Respiratory Medicine in Daqing Oilfield General Hospital, Daqing, Heilongjiang Province, China-163000.
Department of Biochemistry, Centre for Biological Sciences, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal Dt, Tamilnadu-637215.
Department of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
College of Applied Medical Sciences, Majmaah University, Al Majmaah, The Kingdom of Saudi Arabia- 15341; Department of Bio-Medical Engineering, Velalar College of Engineering and Technology, Thindal, Erode-638012, Tamilnadu, India.
ICMR-National Animal Resource Facility for Biomedical Research (NARFBR), Hyderabad, Telangana, India-500007.


In this study, we aimed at assessing the therapeutical potential of 6-gingerol ([5S]-5-hydroxy-1-[4-hydroxy- 3-methoxyphenyl]-3-decanone) against ovalbumin-sensitized asthma in rats. The rats were treated intraperitoneally with 6-gingerol (75 mg/kg body weight) for 30 days and a theophylline (200 mg/kg body weight)-treated group as a control. Changes in the levels of T-cell-linked cytokines (interleukin-4 [IL-4], IL-5, IL-13, and interferon-gamma [IFN-?]), total immunoglobulin E (IgE), gene expressions of bitter taste-sensing type 2-receptor 10 (T2R10), inositol 1,4,5-triphosphate receptor 1 (IP3R1), Orai1 and protein expressions of nuclear factor of activated T cells 1 (NFAT1), c-Myc and histopathological changes were observed in rats. 6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-?. Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline. The histopathological study revealed that the accumulation of glycoprotein and thickness of alveolar epithelium in asthmatic rats and supplementation with 6-gingerol or theophylline in asthmatic rats restored these changes to normal. In conclusion, 6-gingerol has a protective effect on lungs in ovalbumin-sensitized asthma in rats.

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