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J Cell Biochem. 2019 Feb 25. doi: 10.1002/jcb.28449. [Epub ahead of print]

Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.

Author information

1
Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
2
Department of Stomatology, Wuhan Third Hospital, Wuhan, Hubei, People's Republic of China.
3
Department of Oral and Maxillofacial Surgery, Hubei-MOST KLOS & KLOBM, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, People's Republic of China.

Abstract

Long noncoding RNA (lncRNA) mortal obligate RNA transcript (MORT) was downregulated many types of cancer tissues, while its functionality in cancer biology is unclear. In the present study, we systemically investigated the involvement of lncRNA MORT in oral squamous cell carcinoma (OSCC). In the present study, we found that lncRNA MORT was downregulated, while rho-associated coiled-coil containing protein kinase 1 (ROCK1) messenger RNA was upregulated in cancer tissues than in adjacent healthy tissues of OSCC patients. In addition, expression levels of lncRNA MORT and ROCK1 were inversely correlated in both tumor tissues and healthy tissues. Follow-up study showed that low MORT level was significantly correlated with poor survival. Overexpression of lncRNA MORT inhibited the proliferation of OSCC cells and downregulated ROCK1. ROCK1 overexpression led to significantly promoted cell proliferation but showed no significant effect on MORT expression. In addition, ROCK1 overexpression attenuated the inhibitory effects of lncRNA MORT overexpression on the proliferation of OSCC cells. Therefore, lncRNA MORT overexpression may inhibit cancer cell proliferation in OSCC cells by downregulating ROCK1.

KEYWORDS:

ROCK1; lncRNA MORT; oral squamous cell carcinoma; proliferation

PMID:
30805944
DOI:
10.1002/jcb.28449

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