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Int J Gynaecol Obstet. 2019 May;145(2):233-238. doi: 10.1002/ijgo.12798. Epub 2019 Mar 12.

The effects of hysterectomy with bilateral salpingectomy on ovarian reserve.

Author information

1
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Abstract

OBJECTIVE:

To determine whether ovarian reserve is compromised after hysterectomy with bilateral salpingectomy.

METHODS:

A prospective longitudinal study was conducted among 84 women who underwent hysterectomy with bilateral salpingectomy at a tertiary medical center in Beijing, China, between August 2, 2015, and January 15, 2017. Serum levels of anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) were measured to assess ovarian function before undergoing the procedure (baseline) and at weeks 1 and 6 after surgery (postoperative period).

RESULTS:

The median age was 41.61 ± 0.62 years. Age negatively correlated with the serum AMH level at baseline (P<0.001), as well as with preoperative-to-postoperative changes in the concentration of this hormone (P<0.001). Serum AMH levels were lower in the postoperative period versus the preoperative period (P<0.001). By contrast, serum FSH levels were higher in the postoperative period than in the preoperative period (P<0.001). Moreover, no correlation was found with body mass index.

CONCLUSIONS:

Hysterectomy with bilateral salpingectomy compromised ovarian reserve, with the damage being most severe among younger patients.

KEYWORDS:

Anti-Müllerian hormone; Bilateral salpingectomy; Follicle-stimulating hormone; Hysterectomy; Ovarian reserve; Young age

PMID:
30805925
DOI:
10.1002/ijgo.12798

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