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Neuro Oncol. 2019 Feb 26. pii: noz022. doi: 10.1093/neuonc/noz022. [Epub ahead of print]

Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.

Author information

1
University of Michigan Medical School, Ann Arbor, MI.
2
University of Michigan College of Pharmacy, Ann Arbor, MI.
3
NYU School of Medicine, New York City, NY.
4
UCSF Benioff Children's Hospital, San Francisco, CA.
5
Seattle Children's Hospital/University of Washington, Seattle, WA.
6
Dana-Farber Cancer Institute, Boston, MA.
7
Foundation Medicine, Morrisville, NC.
8
Wake Forest School of Medicine, Winston-Salem, NC.
9
Yale Medical School, New Haven, CT.
10
Cincinnati Children's Hospital, Cincinnati, OH.
11
Texas Children's Hospital, Houston, TX.
12
Brigham and Women's Hospital/Harvard Medical School, Boston, MA.

Abstract

As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all four demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

KEYWORDS:

Pediatric; high-grade glioma; low-grade glioma; next-generation sequencing; precision medicine

PMID:
30805642
DOI:
10.1093/neuonc/noz022

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