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Front Genet. 2019 Feb 5;10:20. doi: 10.3389/fgene.2019.00020. eCollection 2019.

Discovering Cancer Subtypes via an Accurate Fusion Strategy on Multiple Profile Data.

Author information

1
School of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.
2
School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
3
School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China.
4
Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, United States.

Abstract

Discovering cancer subtypes is useful for guiding clinical treatment of multiple cancers. Progressive profile technologies for tissue have accumulated diverse types of data. Based on these types of expression data, various computational methods have been proposed to predict cancer subtypes. It is crucial to study how to better integrate these multiple profiles of data. In this paper, we collect multiple profiles of data for five cancers on The Cancer Genome Atlas (TCGA). Then, we construct three similarity kernels for all patients of the same cancer by gene expression, miRNA expression and isoform expression data. We also propose a novel unsupervised multiple kernel fusion method, Similarity Kernel Fusion (SKF), in order to integrate three similarity kernels into one combined kernel. Finally, we make use of spectral clustering on the integrated kernel to predict cancer subtypes. In the experimental results, the P-values from the Cox regression model and survival curve analysis can be used to evaluate the performance of predicted subtypes on three datasets. Our kernel fusion method, SKF, has outstanding performance compared with single kernel and other multiple kernel fusion strategies. It demonstrates that our method can accurately identify more accurate subtypes on various kinds of cancers. Our cancer subtype prediction method can identify essential genes and biomarkers for disease diagnosis and prognosis, and we also discuss the possible side effects of therapies and treatment.

KEYWORDS:

The Cancer Genome Atlas; cancer subtypes prediction; similarity kernel fusion; sparse matrix; spectral clustering

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