Format

Send to

Choose Destination
Occup Environ Med. 2019 May;76(5):332-335. doi: 10.1136/oemed-2018-105518. Epub 2019 Feb 25.

Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study.

Author information

1
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
2
Department of Internal Medicine, Division of Diabetes, Endocrinology, and Metabolism, University of Nebraska Medical Center, Omaha, Nebraska, USA.
3
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
4
Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA.

Abstract

BACKGROUND:

Few studies have evaluated associations between pesticides and hyperthyroidism.

OBJECTIVE:

We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study.

METHODS:

We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders.

RESULTS:

Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (ptrend ≤0.05).

CONCLUSIONS:

Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation.

KEYWORDS:

Agricultural Health Study; hyperthyroidism; pesticides

PMID:
30804163
DOI:
10.1136/oemed-2018-105518

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center