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Trends Cogn Sci. 2019 Apr;23(4):274-277. doi: 10.1016/j.tics.2019.01.013. Epub 2019 Feb 22.

A Dopaminergic Basis for Fear Extinction.

Author information

1
Deutsches Resilienz Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany; Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany. Electronic address: rkalisch@uni-mainz.de.
2
Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.
3
Institute of Neurophysiology, Neuroscience Center, Goethe University, Frankfurt, Germany.

Abstract

It is a joyous relief when an event we dread fails to materialize. In fear extinction, the appetitive nature of an omitted aversive event is not a mere epiphenomenon but drives the reduction of fear responses and the formation of long-term extinction memories. Dopamine emerges as key neurobiological mediator of these related processes.

KEYWORDS:

consolidation; fear conditioning; memory; prediction error; reinforcement learning; reward

PMID:
30803871
DOI:
10.1016/j.tics.2019.01.013

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