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Int J Gynaecol Obstet. 2019 May;145(2):176-181. doi: 10.1002/ijgo.12796. Epub 2019 Mar 13.

Relationships of serum placental growth factor and soluble fms-like tyrosine kinase-1 with fetal and uterine artery Doppler indices in pre-eclampsia.

Author information

1
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Abstract

OBJECTIVE:

To compare serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) concentrations among women with pre-eclampsia and healthy control women and to evaluate the associations of serum PlGF and sFlt-1 with fetal and uterine artery Doppler indices in pre-eclampsia.

METHODS:

A prospective cross-sectional study of 33 women with pre-eclampsia and 33 normotensive pregnant women attending a university hospital in China between January and November 2014. Serum PlGF and sFlt-1 were assayed by enzyme linked immunosorbent assays. Doppler indices of the uterine artery, umbilical artery, fetal middle cerebral artery, and ductus venosus were measured.

RESULTS:

The pulsatility index of the uterine artery was negatively correlated with PlGF (r, -0.487; P=0.004) and positively correlated with sFlt-1 (r, 0.420; P=0.015). Gestational age at birth was positively correlated with PlGF (r, 0.601, P<0.001) and negatively correlated with sFlt-1 (r, -0.568; P=0.001). Birth weight was positively correlated with PlGF (r, 0.555; P=0.001) and negatively correlated with sFlt-1 (r, -0.552; P=0.001). Apgar score was negatively correlated with sFlt-1 (r, -0.427; P=0.017).

CONCLUSION:

Lower PlGF and higher sFlt-1 levels in maternal serum were significantly associated with increased uterine arterial impedance in pre-eclampsia.

KEYWORDS:

Fetal Doppler; Placental growth factor; Pre-eclampsia; Serum biomarkers; Soluble fms-like tyrosine kinase-1; Uterine artery Doppler

PMID:
30801711
DOI:
10.1002/ijgo.12796

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