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J Dairy Sci. 2019 Apr;102(4):2844-2853. doi: 10.3168/jds.2018-15013. Epub 2019 Feb 22.

Effect of the Lactobacillus rhamnosus strain GG and tagatose as a synbiotic combination in a dextran sulfate sodium-induced colitis murine model.

Author information

1
Department of Animal Science and Institute of Milk Genomics, Chonbuk National University, Jeonju 54896, Republic of Korea; Agency of National Food Cluster, Iksan-si, Jeollabuk-do 54576, Republic of Korea.
2
R&D, CJ Cheil Jedang Corporation, Seoul 04560, Republic of Korea.
3
Department of Animal Science and Institute of Milk Genomics, Chonbuk National University, Jeonju 54896, Republic of Korea.
4
Department of Bioenvironmental Chemistry, Chonbuk National University, Jeonju 54896, Republic of Korea.
5
Department of Functional Food and Biotechnology, Jeonju University, Jeonju 55069, Republic of Korea. Electronic address: osangnam@jj.ac.kr.
6
Department of Agricultural Biotechnology, Center for Food and Bioconvergence, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: ykeys2584@snu.ac.kr.

Abstract

Synbiotics, a combination of prebiotics and probiotics, produce synergistic effects to promote gastrointestinal health. Herein, we investigated the synbiotic interaction between the Lactobacillus rhamnosus strain GG (LGG; a probiotic strain) and tagatose (a prebiotic) in a dextran sulfate sodium (DSS)-induced colitis murine model. Initially, body weight, food intake, and clinical features were dramatically decreased after treatment with DSS, and the addition of LGG, tagatose, or both ameliorated these effects. In our pyrosequencing analysis of fecal microbiota, DSS treatment increased the abundance of Proteobacteria and decreased that of Firmicutes. When LGG and tagatose were administered as synbiotics, the gut microbiota composition recovered from the dysbiosis caused by DSS treatment. In particular, the abundance of Bacteroides, Lactobacillus, and Akkermansia was significantly associated with probiotic, prebiotic, and synbiotic treatments. Taken together, our results suggest that LGG and tagatose as synbiotics can alleviate colitis, and synbiotics could be applied as dietary supplements in dairy foods such as yogurt and cheese.

KEYWORDS:

DSS-induced colitis; Lactobacillus rhamnosus GG; gut microbiota; synbiotic; tagatose

PMID:
30799108
DOI:
10.3168/jds.2018-15013
[Indexed for MEDLINE]

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