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Br J Ophthalmol. 2019 Feb 23. pii: bjophthalmol-2018-313356. doi: 10.1136/bjophthalmol-2018-313356. [Epub ahead of print]

Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis.

Author information

1
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan m.manabu.oph@tmd.ac.jp.
2
Miyata Eye Hospital, Miyakonojo, Japan.
3
Flinders University School of Medicine and Public Health, Adelaide, South Australia, Australia.
4
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
5
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
6
F. I. Proctor Foundation and Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
7
Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Abstract

AIMS:

International criteria for the diagnosis of ocular sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria.

METHODS:

A consensus workshop was carried out to discuss and revise the IWOS criteria. The workshop was held on 27 April 2017, in Nusa Dua, Bali, Indonesia. Prior to the workshop, a questionnaire proposing revised criteria and consisting of one item for differential diagnosis, seven items for ocular clinical signs, 10 items for systemic investigations and three categories of diagnostic criteria was circulated to 30 uveitis specialists. Questionnaire items with over 75% support were taken as consensus agreement; items with below 50% support were taken as consensus disagreement and items with 50%-75% support were discussed at the workshop. Of the latter items, those supported by two-thirds majority in the workshop were taken as consensus agreement.

RESULTS:

The survey and subsequent workshop reached consensus agreements of the revised criteria for the diagnosis of OS as follows: (1) other causes of granulomatous uveitis must be ruled out; (2) seven intraocular clinical signs suggestive of OS; (3) eight results of systemic investigations in suspected OS and (4) three categories of diagnostic criteria depending on biopsy results and combination of intraocular signs and results of systemic investigations.

CONCLUSIONS:

Revised IWOS criteria were proposed by a consensus workshop.

KEYWORDS:

inflammation

Conflict of interest statement

Competing interests: None declared.

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