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Alzheimers Dement. 2019 Apr;15(4):497-505. doi: 10.1016/j.jalz.2018.12.006. Epub 2019 Feb 20.

Incidence of dementia after age 90 in a multiracial cohort.

Author information

1
Kaiser Permanente Division of Research, Oakland, CA, USA.
2
Department of Neurology, University of California, Irvine, Irvine, CA, USA; Department of Epidemiology, University of California, Irvine, Irvine, CA, USA.
3
Department of Neurology, University of California, Irvine, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
4
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
5
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
6
Kaiser Permanente Division of Research, Oakland, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA; Department of Public Health Sciences, University of California, Davis, Davis, CA, USA. Electronic address: rawhitmer@ucdavis.edu.

Abstract

INTRODUCTION:

Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence.

METHODS:

Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life.

RESULTS:

Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities.

DISCUSSION:

Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.

KEYWORDS:

Dementia; Disparities; Epidemiology; Ethnicity; Oldest-old; Race

PMID:
30797730
PMCID:
PMC6497045
[Available on 2020-04-01]
DOI:
10.1016/j.jalz.2018.12.006

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