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Trends Endocrinol Metab. 2019 Apr;30(4):225-227. doi: 10.1016/j.tem.2019.02.004. Epub 2019 Feb 21.

NR Supplementation During Lactation: Benefiting Mother and Child.

Author information

1
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
2
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: yihong.wan@utsouthwestern.edu.

Abstract

Abnormal nicotinamide adenine dinucleotide (NAD+) metabolism causes a wide spectrum of diseases. A recent study (Cell Rep. 2019;26:969-983) shows that postpartum NAD+ homeostasis is depressed. By restoring NAD+ homeostasis, maternal nicotinamide riboside (NR) supplementation during lactation enhances postpartum weight loss, as well as juvenile development and adult neurogenesis in the offspring.

KEYWORDS:

NAD(+) metabolism; neurogenesis; nicotinamide riboside; offspring development; postpartum; weight loss

PMID:
30797625
DOI:
10.1016/j.tem.2019.02.004

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