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Am J Med Sci. 2019 Mar;357(3):223-229. doi: 10.1016/j.amjms.2018.12.005. Epub 2018 Dec 13.

Role of Vitamin D and Its Analogues in Diabetic Nephropathy: A Meta-analysis.

Author information

1
Department of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut. Electronic address: gupta.sonali2706@gmail.com.
2
The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut; Department of Radiology, St. Vincent's Medical Center, Bridgeport, Connecticut.
3
Department of Medical Sciences, The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut.
4
Department of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut.

Abstract

BACKGROUND:

Diabetic nephropathy remains one of the most common causes of chronic kidney disease in the United States and is associated with significant morbidity and mortality. Recently, there have been emerging data highlighting the role of vitamin D and its analogue in chronic kidney disease especially diabetic nephropathy independent of its effect on bone metabolism.

METHODS:

This study aimed to evaluate effect of supplementing vitamin D and its analogues on halting or slowing progression of diabetic nephropathy. Electronic databases (PubMed, Scopus, Google scholar) were searched and randomized controlled trials (RCTs) that investigated the use of vitamin D and its analogs for diabetic nephropathy were studied. This meta-analysis of RCTs performed in accordance with Preferred Reporting Items for Systematic review and Meta-analysis statement.

RESULTS:

This meta-analysis included 9 RCTs and suggested a favorable trend with respect to an effect of vitamin D and its analogues on albuminuria though this did not reach statistical significance (MD, -0.17; 95% CI, -0.34-0.01; P = 0.06]. Serum calcium was unaffected suggesting safe use of these agents.

CONCLUSIONS:

Use of vitamin D and its analogues may have potential as an adjuvant therapy for reducing albuminuria and slowing progression of diabetic nephropathy but further studies are needed.

KEYWORDS:

Chronic kidney disease; Diabetic nephropathy; Vitamin D

PMID:
30797503
DOI:
10.1016/j.amjms.2018.12.005
[Indexed for MEDLINE]

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