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Ann Hematol. 2019 May;98(5):1051-1069. doi: 10.1007/s00277-019-03622-0. Epub 2019 Feb 22.

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO).

Author information

1
Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. Matthias.Kochanek@uk-koeln.de.
2
Intensive Care in Hematologic and Oncologic Patients (iCHOP), Cologne, Germany. Matthias.Kochanek@uk-koeln.de.
3
Intensive Care in Hematologic and Oncologic Patients (iCHOP), Cologne, Germany.
4
Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
5
Medical Department III, University Medical Center & Comprehensive Cancer Center Munich, Munich, Germany.
6
Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation Hannover Medical School, Hannover, Germany.
7
Department of Hematology and Oncology, Mannheim University Hospital, Mannheim, Germany.
8
Department of Medicine III - Hematology and Oncology, Red Cross Hospital, Munich, Germany.
9
Department of Medicine, Clinic III - Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, Rostock, Germany.
10
Department of Internal Medicine I, Clinic Frankfurt (Oder), Frankfurt, Germany.
11
Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
12
Department for Hematology and Medical Oncology, University Hospital Jena, Jena, Germany.
13
Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
14
Department for Hematology, Oncology and Tumorimmunology, Campus Virchow Clinic, Charité Universitätsmedizin Berlin, Berlin, Germany.
15
Department of Hematology, Oncology and Infectious Diseases, Klinikum Bremen-Mitte, Bremen, Germany.

Abstract

Sepsis and septic shock are major causes of mortality during chemotherapy-induced neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting characteristics and prompt management is most important. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. However, optimal management may differ between neutropenic and non-neutropenic patients. The aim of the current guideline is to give evidence-based recommendations for hematologists, oncologists, and intensive care physicians on how to manage adult patients with neutropenia and sepsis.

KEYWORDS:

Cancer; Guideline; Management; Neutropenia; Sepsis; Septic shock

PMID:
30796468
DOI:
10.1007/s00277-019-03622-0

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